- 1 - Phospholipase C - related , but catalytically inactive protein PRIP modulates SNAP - 25 phosphorylation and exocytosis

نویسندگان

  • Jing Gao
  • Hiroshi Takeuchi
  • Zhao Zhang
  • Mitsunori Fukuda
  • Masato Hirata
چکیده

Background: Phospho-modulation of SNARE function has not yet known. Results: Phospho-SNAP-25 was de-phosphorylated by protein phosphatase-1 whose activity was regulated by PRIP, thus regulating exocytosis. Conclusion: Protein phosphatase-1 whose activity is regulated by PRIP, is the major phosphatase responsible for the de-phosphorylation of SNAP-25. Significance: The results provide the first information regarding the phosphatases responsible for phospho-modulation of SNAP-25 and the regulation of exocytosis.

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تاریخ انتشار 2012